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Resident Evil 2 is designed for multiple runs through its campaign, so it can vary depending on whether it's your first or second time through. Here's the thing about Resident Evil 2 campaigns for Leon and Claire: there aren't two campaigns, there are four.
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Still, here are the campaign differences-time for a Leon vs. Which one you should do first is something of a judgment call. So while your first big decisions is whether to play Leon or Claire, there's every incentive to go through the campaign again as the other character. The Resident Evil 2 remake has a fairly short campaign-it took me about eight and a half hours-but it's what you do after beating the campaign that gets interesting, when a wealth of options open up.
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